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The Best Supplements for SIBO Support (With Science & Product Links) Small Intestinal Bacterial Overgrowth (SIBO) is a condition in which excess bacteria accumulate in the small intestine, leading to symptoms like bloating, gas, abdominal discomfort, and nutrient malabsorption. While antibiotics are often prescribed, many people seek natural or supplemental support as part of a comprehensive approach. Research suggests that herbal antimicrobials, digestive support formulas, and certain non-b …